Right now, it's only available to be seen on Qubo Channel, which pretty much everyone gets as an over-the-air digital channel (but has no cable distribution). It's a subchannel of Ion (formerly PAX), and most of the time they only show feeble edutainment. At night they do show a few classic Filmation cartoons (He-Man/She-Ra, Ghostbusters — the one based on the 1970s live-action TV series "The Ghost Busters," not the one with Lorenzo Music as Bill Murray — and the like). And then at 1:00 AM (Pacific), they show Spliced!.
The overall plot is basically a modernized, cartoon version of what comes after The Island of Doctor Moreau. A mad scientist created a whole bunch of critters out of other species, and imbued most of them with human-esque intelligence. At an unspecified time before the cartoon, he got imprisoned for unspecified crimes, and the island was left to flourish on its own.
The main characters are Èntree (a cowchickenpigshrimp, engineered to be the ultimate meal) and Experiment "Peri" 13 (a cuttlesquirrel, engineered to be). They aren't protagonists so much as the idiots who cause problems for everyone else. There's also a supervillain, Mr. Smarty Smarts (a hyperintelligent dolphin with human arms and a gigantic ego and insecurity complex), but nobody seems to see him as a supervillain except for Mr. Smarty Smarts himself (unless it's convenient to the plot).
The show is exceptionally well-written, and the low-budget Flash animation takes advantage of the medium. Characters are well-acted, there's some great visual gags, and the stories tend to be classic short-style. But they don't stick to a specific length; they're perfectly okay with a story being only 30 seconds long if that's all that's necessary.
In the US, Spliced! is exclusive to Qubo, where it's an odd one out. Most of the shows there are very specifically for kids, and are all about "positive encouragement" and firm family values and whatnot. Spliced! is just about having fun, and it does so in ways that really tweak the family values crowd. (One of the most blatant ones is that Èntree wasn't engineered to be mobile, but he learned how to walk around on his udder. Yes, he has an udder. Yes, it produces milk.) Even Nelvana only relegates Spliced! to what is essentially a footnote.
There are a few episodes on YouTube (in pretty low quality, unfortunately), which at least gives you a taste for the show.