Today’s ADHD medication discovery

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Dextroamphetamine on its own has been working pretty well for me for the last few days, and my blood pressure has been only slightly elevated (not to the point that I could feel it).

Today I decided to try using a small amount of cannabis as well, and within half an hour I felt my blood pressure spike. It’s “only” 140/90, which is pretty elevated and enough for me to feel it, but not enough to worry about.

Anyway, I looked it up and there have indeed been a couple studies that have found that THC and dextroamphetamine interact to cause a blood pressure spike. Oops.

I don’t remember which particular strain I had loaded up in my vaporizer; it’s either Harlequin (which is 95% CBD) or Lemon Smac (which is 100% THC). So I’ll need to try a more careful experiment in the future to make sure I’m even using the right strain to begin with, but I don’t think I’ll be doing that any time soon. I’ll also probably want to try it with something that’s nearly 100% CBD just to be relatively-safe.

Dextroamphetamine, day 1

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I took my little 10mg capsule when I woke up at 8 AM, and I felt it kick in during my shower. It’s led to a feeling of clarity and less chaos in my brain. I did a few put-off chores before work, and at work I’m not feeling totally overwhelmed by stuff. I’m still not focusing on what I mean to be working on, though.

Blood pressure is 131/89, heart rate is 65. Slightly elevated from my baseline but definitely nothing to be worried about. My hands are also slightly shakier than usual but not, like, alarmingly so.

This shows some promise and I’ll be working to adjust the dosage and timing accordingly. I might try supplementing with a caffeine microdose later today.

Also, last night was my first dose of fenofibrate, which hasn’t solved all my pain issues overnight but I’d expect that to take a week or so to be effective.

Pain, fatigue, and focus

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Two weeks since my last ketamine infusion and my anxiety is… present, again, and my chronic pain never went away at all but now I’m feeling a lot more aware of it.

I went back and tried Adderall again and it didn’t mess me up, although it also didn’t help me like it did the last time I tried it. But neither Adderall nor caffeine are messing with my blood pressure or increasing my anxiety, so I’ve reopened the conversation with my doctor regarding other meds for ADHD. In particular, I asked about Dexedrine and Desoxyn. Both of them seem promising at the dosages I’m looking at, although my insurance won’t cover Desoxyn (which is unsurprising, there was a TV series about it) so we’re trying Dexedrine first.

Regarding chronic pain, my doctor went over my chart and he noticed that we never really did anything about my high triglycerides, and then he had a thought: what if my high triglycerides are contributing to my fibro symptoms? Doing some cursory literature search found that it’s plausible, at least, so I’m also going to start on Fenofibrate to lower my triglycerides and hopefully get my body in some sort of balance there. He’s also ordered some more labwork to see if I have any gaping vitamin deficiencies.

Have I mentioned how much I cherish this doctor? Of all the doctors I’ve seen, this is the only one where I feel like he actually listens to me, doesn’t talk down to me, understands that I know my body and have done my reserach, and is willing to try things to attempt to treat these complex, deep-seated issues that have caused me problems for the past 25-odd years. It’s a lot easier to be patient as a patient when the healthcare provider treats me with respect like this.

He’s definitely a rare breed.

Ketamine 4.1

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On the plus side, my focus is way higher, and my anxiety is the lowest it’s been in a decade.

On the minus side, my chronic pain still sucks a lot, and this is still making it very hard for me to do my job.

It’s still been a huge net benefit for me though. And supposedly it takes a little while for ketamine treatments to have an effect on chronic pain. I’ll get there eventually.

I spoke too soon

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Maybe I should have been checking my blood pressure more frequently. I didn’t check it at all yesterday like I should have and just assumed it was fine, because I just woke up at 4:40 AM feeling a bit off and on a hunch I checked my blood pressure… which is now 169/86.

Wellp, so much for my last chance at being medicated.

Vyvanse continuing

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So I’ve been on Vyvanse for many days now. Four total, one last Friday and three this week.

So far it isn’t really helping me, but it also isn’t hurting me. This is also just like the lowest possible dose for trial purposes, though.

It makes me feel awake and a bit alert. I also feel like I’m a bit more prone to irritation and feeling stressed, but that might just be other situational things happening right now. It hasn’t really helped with focus at all.

My heart rate and blood pressure are slightly higher than usual but not alramingly so.

I think it’ll be worth trying the next dosage up at some point. I have a followup with my doctor next week to discuss that. It’s promising.

Today I drove for the first time while on it and boy howdy did that feel weird. I’ll probably want to go without it during my trip in a few weeks.

We’ll see how I feel this weekend.

Vyvanse, day 1

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Today was my first day trialing Vyvanse, just a single 10mg dose in the morning. I took it at around 9 AM, and felt it kick in at around 10. It gave me a slight headache, and a slight vague spacy feeling, with maybe a bit of… something that I’m having trouble describing. Almost like my spine was being squeezed from the inside? I don’t know.

My blood pressure and heart rate did rise up a little, but not to concerning levels; my rest pulse is usually 50-60 and my BP is usually 120/80, and on Vyvanse it peaked at around 75 and 135/85, respectively. Nothing terribly concerning, and not so much that I could feel it myself.

I don’t feel like I’m specifically more focused than usual, although my headspace is at least a bit less cluttered. And I’m definitely more alert than usual. It’s not quite how I felt on the two good days of Adderall, but it’s also not like, say, Concerta or Strattera which had me feeling frustrated and, well, colicky, for lack of a better term.1

Anyway. It was good to try this experiment on a day right before a weekend, since that means it won’t mess up the rest of my week if something went wrong, and also this was on a day I wasn’t expecting to be very productive anyway, what with the everything. I’ll be skipping it over the weekend but now I’m feeling a lot more optimistic about resuming it on Monday.

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Armodafinil followup

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Just a followup, I ended up staying awake for over 25 hours, finally fell asleep for a bit today at 10, woke up again at 11, and mostly I’m feeling like I have a gigantic hangover.

Apparently armodafinil’s mechanism of action is identical to cocaine’s, so it actually IS stimulant-based and not just “a wakefulness agent” and I wish i’d known that before embarking on this. I don’t know why my research failed me this badly this time. Probably me being desperate for something that works.

I’m definitely not interested in continuing with armodafinil, in any case. Advice for dealing with this massive pounding headache would be appreciated.

sleepless from armodafinil

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i feel like crap and i;m wide awake and i want to sleep but i can;t sleep

i;ve been having electric pains through my nerves all night and i feel like i drank three pots of coffee and i am not sleepy at all but i am very very tired

on the plus side i’m having no apnea symptoms tonight but that’s because i’m not getting into a state of relaxation which allows it to occur in the first place

why is my body so awful at processing medications