Back in November of 2017 I had a pulmonary embolism, the result of a DVT which was the result of a combination of risk factors. At the time that it occurred, the insistence from the hematologist was that I’d have to cease the use of estradiol entirely, and this led to the worst month of physical and mental health that I can remember. I was basically going through menopause. A month later, a different hematologist said there was no reason I couldn’t keep taking estradiol, especially since I was on a course of warfarin to clear up remaining clot.
A couple years after that I had another minor DVT, and this led to needing to be on blood thinners, so now I take Xarelto daily, and likely will for the rest of my life.